Polymeric additives to enhance the functional properties of calcium phosphate cements
نویسندگان
چکیده
The vast majority of materials used in bone tissue engineering and regenerative medicine are based on calcium phosphates due to their similarity with the mineral phase of natural bone. Among them, calcium phosphate cements, which are composed of a powder and a liquid that are mixed to obtain a moldable paste, are widely used. These calcium phosphate cement pastes can be injected using minimally invasive surgery and adapt to the shape of the defect, resulting in an entangled network of calcium phosphate crystals. Adding an organic phase to the calcium phosphate cement formulation is a very powerful strategy to enhance some of the properties of these materials. Adding some water-soluble biocompatible polymers in the calcium phosphate cement liquid or powder phase improves physicochemical and mechanical properties, such as injectability, cohesion, and toughness. Moreover, adding specific polymers can enhance the biological response and the resorption rate of the material. The goal of this study is to overview the most relevant advances in this field, focusing on the different types of polymers that have been used to enhance specific calcium phosphate cement properties.
منابع مشابه
Influence of polymeric additives on the cohesion and mechanical properties of calcium phosphate cements
To expand the clinical applicability of calcium phosphate cements (CPCs) to load-bearing anatomical sites, the mechanical and setting properties of CPCs need to be improved. Specifically, organic additives need to be developed that can overcome the disintegration and brittleness of CPCs. Hence, we compared two conventional polymeric additives (i.e. carboxylmethylcellulose (CMC) and hyaluronan (...
متن کاملInvestigation of Macroporous Calcium Phosphate Cement Obtained by Foamed Gelatin Polymer
This study deals with the effect of gelatin on physical and mechanical properties of calcium phosphate bone cements. The mixture of tetracalcium phosphate (TTCP) and dicalcium phosphate (DCPA) as the cement powder was mixed with 6 wt% Na2HPO4 solution containing different amount (0, 2, 5 and 8% in w/w) of foamed gelatin as liquid phase. The physical properties were determined in the terms of s...
متن کاملOptimization of an acidic calcium phosphate cement with enhanced radiopacity
Optimization of an acidic calcium phosphate cement with enhanced radiopacity. INTRODUCTION: Calcium phosphate cements (CPCs) are commonly used in biomedical applications due to their resemblance to the mineral phase of bone. However, due to this resemblance the radiopacity of CPC is very similar to that of bone. The inorganic radiopacifiers (e.g. ZrO 2 and BaSO 4) commonly used in non degradabl...
متن کاملMolecular mechanisms of crystallization impacting calcium phosphate cements.
The biomineral calcium hydrogen phosphate dihydrate (CaHPO(4).2H(2)O), known as brushite, is a malleable material that both grows and dissolves faster than most other calcium minerals, including other calcium phosphate phases, calcium carbonates and calcium oxalates. Within the body, this ready formation and dissolution can play a role in certain diseases, such as kidney stone and plaque format...
متن کاملEffect of Graphene Oxide Nanoparticles Addition on Mechanical and Biological Properties of Calcium Phosphate Cement
In the present study, we have evaluated the effects of graphene oxide (GO) addition on the physical-mechanical-biological properties of calcium phosphate cement (CPC). The in vitro cellular responses of MG63 and in vivo tissue responses after the implantation of CPC/GO in parietal bone defects of wistar rats were also investigated. The brushite calcium phosphate cements were prepared by mixi...
متن کامل